Clear Visibility. Precise Treatment.
MRI-Visible Fiducial Markers for Proton Therapy, Brachytherapy, Radiotherapy, and image-guided Surgical procedures for Tumor Localization and Treatment Planning.
What Happens When
You Can't See Clearly?
Conventional markers distort images, making precision treatment harder. C4 Imaging markers reduce distortion and improve planning for safer, more effective therapy.
What Happens When You Can't See Clearly?
Conventional markers distort images, making precision treatment harder. C4 Imaging markers reduce distortion and improve planning for safer, more effective therapy.
Non-Metallic MRI Visible Markers
Designed to improve accuracy across all Radiotherapy modalities, including Proton Therapy and External Beam Treatments.
NOVA
Non-metallic fiducial markers designed for accurate targeting in Proton Therapy, Radiotherapy, and image-guided Surgical procedures for Tumor Localization and Treatment Planning.
ORION
Advancing High Dose Rate (HDR) Brachytherapy: Precision. Efficiency. Confidence.
SIRIUS
Low Dose Rate (LDR) Brachytherapy: pinpoint prostate seeds within the surrounding structures with a single MRI, improving quality assurance and eliminating the need for CT.
From the Founder
Steven J. Frank, MD is the Founder of C4 Imaging and a Professor of Radiation Oncology at MD Anderson Cancer Center. He started C4 Imaging in 2010 with a heartfelt vision: to give patients and physicians greater confidence in Cancer Treatment by making imaging clearer and more reliable. Inspired by his daily work caring for patients, Dr. Frank pioneered the world’s first positive-signal MRI marker, SIRIUS, which opened the door to new possibilities in precision care. This breakthrough became the foundation for C4 Imaging’s growing family of products, including ORION for HDR brachytherapy and NOVA for External Beam Radiation therapy. What began as a single innovation is now a shared mission – to reduce uncertainty, improve outcomes, and bring clarity and peace of mind to every patient’s journey through Cancer Care.
Precision You Can See. Confidence You Can Trust.
Physicians in the Radiation Oncology community trust C4 Imaging to deliver imaging visibility and anatomical detail, advancing MRI-enhanced Brachytherapy, Proton Therapy, and Radiotherapy.
Precision You Can See. Confidence You Can Trust.
Physicians in the Radiation Oncology community trust C4 Imaging to deliver imaging visibility and anatomical detail, advancing MRI-enhanced Brachytherapy, Proton Therapy, and Radiotherapy.
Clinician Endorsements
Trusted Insights from Leaders on the Frontline of Cancer Care.
Dr. Andrew Farach
Houston Methodist Hospital
“NOVA provides crisp, reliable visibility across ultrasound, CT, and MRI-offering the only MRI-positive, non-metallic fiducial marker available. This clarity has significantly enhanced our MRI fusion workflows for Brachytherapy, SBRT, and EBRT, enabling more confident targeting and safer, more precise care.”
Dr. Peter Rossi
Callaway-Young Cancer Center Valley View
“In my practice, NOVA is revolutionizing precision medicine. It boasts the lowest dose perturbation, eliminates CT streak and MRI susceptibility artifacts, and offers fast and efficient MRI-CT fusion treatment planning. With NOVA, I can deliver targeted therapy like never before.”
Dr. Shalin Shah
UT MD Anderson
“NOVA really accelerates our ability to attain zero harm. That’s our holy grail – is to treat our patients to the best of our abilities, cure their cancer, but then achieve zero harm. I think NOVA helps us get to that goal.”
Your Next Step
Starts Here
Whether it’s product details, clinical support, or partnership opportunities, our team is ready to help.